serotonin [5HT]-2C receptor; 5-hydroxytryptamine receptor 2C; 5-HTR2C; 5-HT-2C; 5-HT2C; 5HT-1C; serotonin receptor 2C (HTR2C, HTR1C)
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Function
- one of several receptors for 5-hydroxytryptamine (serotonin)
- mediates its action by association with G proteins that activate a phosphatidylinositol-Ca+2 second messenger system
- interacts with MPDZ
- tonic inhibition of a neuronal excitatory network[2] (see pathology)
Structure
- The PDZ domain-binding motif is involved in the interaction with MPDZ
- belongs to the G-protein coupled receptor 1 family
- N-glycosylated
Compartment
Genetics
- RNA editing
- modified positions=156, 158, 160
- partially edited
- RNA editing generates receptor isoforms that differ in their ability to interact with the phospholipase C signaling cascade in a transfected cell line, suggesting a role in modulation of serotonergic neurotransmission in the CNS
Polymorphism
- position 23 is polymorphic
- frequencies in unrelated Caucasians are 0.87 for Cys & 0.13 for Ser
Laboratory
Comparative biology
- 5-HT 2C receptor-deficient mice are
- overweight as a result of abnormal control of feeding behavior
- prone to spontaneous death from seizures suggesting a role in tonic inhibition of a neuronal excitatory network[2]
Notes
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/P28335.html
- ↑ 2.0 2.1 2.2 2.3 Tecott LH, Sun LM, Akana SF, Strack AM, Lowenstein DH, Dallman MF, Julius D. Eating disorder and epilepsy in mice lacking 5-HT2c serotonin receptors. Nature. 1995 Apr 6;374(6522):542-6. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7700379
- ↑ Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3358