serotonin [5HT]-2C receptor; 5-hydroxytryptamine receptor 2C; 5-HTR2C; 5-HT-2C; 5-HT2C; 5HT-1C; serotonin receptor 2C (HTR2C, HTR1C)

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Function

Structure

Compartment

cell membrane

Genetics

Polymorphism

Laboratory

Comparative biology

  • 5-HT 2C receptor-deficient mice are
    • overweight as a result of abnormal control of feeding behavior
    • prone to spontaneous death from seizures suggesting a role in tonic inhibition of a neuronal excitatory network[2]

Notes

  • previously, termed 5-HT 1C receptor[2]

More general terms

References

  1. UniProt http://www.uniprot.org/uniprot/P28335.html
  2. 2.0 2.1 2.2 2.3 Tecott LH, Sun LM, Akana SF, Strack AM, Lowenstein DH, Dallman MF, Julius D. Eating disorder and epilepsy in mice lacking 5-HT2c serotonin receptors. Nature. 1995 Apr 6;374(6522):542-6. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7700379
  3. Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3358

Database