junctional adhesion molecule A; JAM-A; junctional adhesion molecule 1; JAM-1; platelet F11 receptor; platelet adhesion molecule 1; PAM-1; CD321 (F11R, JAM1, JCAM, UNQ264/PRO301)

Function

• seems to plays a role in epithelial tight junction formation
• appears early in primordial forms of cell junctions & recruits PARD3
• association of the PARD6-PARD3 complex may prevent interaction of PARD3 with JAM1, thereby preventing tight junction assembly
• role in regulating monocyte transmigration involved in integrity of epithelial barrier
• role in platelet activation
• interacts with the ninth PDZ domain of MPDZ
• interacts with the first PDZ domain of PARD3;
  • association of PARD3 & PARD6B probably disrupts this interaction

Structure

• N-glycosylated
• belongs to the immunoglobulin superfamily
• contains 2 Ig-like V-type domains

Compartment

• cell junction, tight junction
• cell membrane; single-pass type 1 membrane protein
• localized at tight junctions of both epithelial cells & endothelial cells

Pathology

• receptor for orthoreovirus
• interacts with the orthoreovirus sigma-1 capsid protein (putative)

More general terms

• junctional adhesion molecule
• phosphoprotein
• CD antigen

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=50848
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:50848
• OMIM: https://mirror.omim.org/entry/605721
• UniProt: http://www.uniprot.org/uniprot/Q9Y624.html