partitioning-defective 3 homolog (PARD-3 ,PAR-3, atypical PKC isotype-specific-interacting protein, ASIP, CTCL tumor antigen se2-5, PAR3-alpha, PARD3, PAR3, PAR3A)

Function

• adapter protein involved in asymmetrical cell division & cell polarization processes
• role in formation of epithelial tight junctions
• association with PARD6B inhibits interaction with F11R/JAM1, thus preventing tight junction assembly (putative)
• PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins
• interacts with PARD6A & PARD6B
• isoform 2, but not at least isoform 3 interacts with PRKCZ
• interacts with PRCKI
• component of complex with PARD6A or PARD6B, PRKCI or PRKCZ & CDC42 or RAC1
• interacts with F11R/JAM1
• phosphorylated by PRKCZ

Structure

• belongs to the PAR3 family.
• contains 3 PDZ (DHR) domains

Compartment

• intracytoplasmic membrane, cell junction, cell membrane
• partially localized along the cell-cell contact region
• colocalizes with PARD6A & PRKCI at epithelial tight junctions

Alternative splicing

named isoforms=10

Expression

widely expressed

Pathology

• autoantibodies against PARD3 are present in sera from patients with cutaneous T-cell lymphoma

More general terms

• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/606745
• UniProt: http://www.uniprot.org/uniprot/Q8TEW0.html