partitioning defective 6 homolog alpha (PAR-6 alpha, PAR-6A, PAR-6,PAR6C, tax interaction protein 40, TIP-40, PARD6A, PAR6A)

Function

• adapter protein involved in asymmetrical cell division & cell polarization processes
• formation of epithelial tight junctions (putative)
• association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly
• PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins
  • pseudo-CRIB domain together with the PDZ domain is required for the interaction with Rho small GTPases
• interacts with MAP2K5 (putative)
  • OPR domain mediates interactions with MAP2K5
• interacts with PARD3
• interacts with GTP-bound forms of CDC42, ARHQ/TC10 & RAC1
• interacts with the N-terminal part of PRKCI & PRKCZ
• interacts with human T-cell leukemia virus type 1 TAX protein
• interacts with MPP5 & CRB3
• component of complex with PARD3, CDC42 or RAC1 & PRKCI or PRKCZ
• component of complex with LLGL1 & PRKCI

Compartment

• cytoplasmic
• colocalizes with GTP-bound CDC42 or RAC1 at membrane ruffles & with PARD3 & PRKCI at epithelial tight junctions

Expression

• expressed in pancreas, skeletal muscle, brain, heart > kidney, placenta

More general terms

• cytoskeletal protein

Database

• OMIM: https://mirror.omim.org/entry/607484
• UniProt: http://www.uniprot.org/uniprot/Q9NPB6.html