MAGUK p55 subfamily member5; membrane protein palmitoylated 5 (MPP5)

Function

• biogenesis of tight junctions
• establishment of cell polarity in epithelial cells
• modulation of SC6A1-mediated GABA uptake
  • stabilizes transporter
• localization of VIL2 to apical membrane of parietal cells
• dynamic remodeling of apical cytoskeleton (putative)
• interacts with the LIN7, CRB3 & MPDZ INADL, PARD6B, SC6A1, VIL2
• forms a complex with CRB1 & MPP4
• component of a complex whose core is composed of ARHGAP17, AMOT, MPP5/PALS1, INADL/PATJ & PARD3/PAR3
• heterodimer with MPP1
• interacts with MPP7

Structure

• the L27 domain 1 functions in targeting to tight junctions by binding to INADL (putative)
• the PDZ domain binds to the C-terminus of SC6A1
• belongs to the MAGUK family
• contains 1 guanylate kinase-like domain
• contains 2 L27 domains
• contains 1 PDZ domain (DHR domain)
• contains 1 SH3 domain

Compartment

• cell membrane; peripheral & intracellular membranes
• tight junctions of epithelial cells
• subset of intracellular vesicles
• in retina:
  • outerlimiting membranes
  • apical to the adherens junction
  • colocalizes with CRB1
• Purkinje cell body & axon

Alternative splicing

named isoforms=2

Expression

• expressed in the retina, cerebellar Purkinje cells

More general terms

• membrane protein
• MAGUK p55 subfamily
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=64398
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:64398
• OMIM: https://mirror.omim.org/entry/606958
• UniProt: http://www.uniprot.org/uniprot/Q8N3R9.html