angiomotin (AMOT, KIAA1071)

Function

• role in maintenance of tight junctions via complex with ARHGAP17, which acts by regulating uptake of polarity proteins at tight junctions
• appears to regulate endothelial cell migration & tube formation (blood vessel formation)
• may also play a role in assembly of endothelial cell- cell junctions
• phosphorylated upon DNA damage, probably by ATM or ATR
• polyubiquitinated by NEDD4, NEDD4L & ITCH, leading to proteasomal degradation
• component of a complex whose core is composed of ARHGAP17, AMOT, MPP5/PALS1, INADL/PATJ & PARD3/PAR3
• interacts with MAGI1
• isoform 1 interacts with angiostatin

Structure

• the coiled coil domain interacts directly with the BAR domain of ARHGAP17
• the angiostatin binding domain (871-1005) allows binding to angiostatin
• belongs to the angiomotin family

Compartment

• cell junction, tight junction
• localized on the cell surface
• may act as a transmembrane protein

Alternative splicing

named isoforms=2

Expression

• expressed in placenta, skeletal muscle, endothelial cells of capillaries & larger vessels of placenta

Notes

'Motus' means 'motility' in latin

More general terms

• membrane protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=154796
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:154796
• OMIM: https://mirror.omim.org/entry/300410
• UniProt: http://www.uniprot.org/uniprot/Q4VCS5.html