Rho GTPase-activating protein 17 (Rho-type GTPase-activating protein 17, RhoGAP interacting with CIP4 homologs protein 1, RICH-1, ARHGAP17, RICH1, MSTP066, MSTP110)

Function

• Rho GTPase-activating protein
• role in maintenance of tight junction by regulating activity of CDC42, thus modulating apical polarity of epithelial cells
• GTPase activator for CDC42 GTPase
• forms complex with AMOT that regulates uptake of polarity proteins at tight junctions, possibly by sorting tight junction transmembrane proteins for recycling back to the plasma membrane or sent elsewhere
• role in Ca+2-dependent regulation of exocytosis, possibly via catalyzing GTPase activity of Rho family proteins & by inducing reorganization of cortical actin filaments
• GTPase activitor in vitro for RAC1
• component of a complex whose core is composed of ARHGAP17, AMOT, MPP5/PALS1, INADL/PATJ & PARD3/PAR3
• interacts with SLC9A3R1, FNBP1, TRIP10, CAPZA (CAPZA1, CAPZA2 or CAPZA3), CAPZB, CD2AP & SH3KBP1/CIN85

Structure

• contains 1 BAR domain
• contains 1 Rho-GAP domain

Compartment

• peripheral membrane, cytoplasm, cell junction, tight junction
• associates with membranes & concentrates at sites of cell-cell contact

Alternative splicing

named isoforms=7

Expression

• ubiquitously expressed
• expressed at higher level in heart & placenta
• BAR domain mediates interaction with coiled coil domain of AMOT, leading to its recruitment to tight junction

More general terms

• rho GTPase-activating protein (rho-GAP)
• membrane protein
• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/608293
• UniProt: http://www.uniprot.org/uniprot/Q68EM7.html