CDC42 homolog; cell division control protein 42 homolog; G25K GTP-binding protein (CDC42)

Function

• plasma membrane-associated small GTPase & guanine-nucleotide regulatory protein.
• bound by proteins containing CRIB domain
• role in epithelial cell polarization processes
• induces formation of filopodia
• interacts with CDC42EP1, CDC42EP2, CDC42EP3, CDC42EP4, CDC42EP5, CDC42SE1, CDC42SE2, PARD6A, PARD6B & PARD6G (GTP-dependent)
• interacts with activated CSPG4 & with BAIAP2
• interacts with Zizimin1/DOCK9 & Zizimin2/DOCK11, which activate it by exchanging GDP for GTP.
• interacts with NET1 & TCGAP/SNX26
• part of a complex with PARD3, PARD6A or PARD6B & PRKCI or PRKCZ

Structure

• belongs to the small GTPase superfamily, Rho family CDC42 subfamily

Compartment

• cell membrane; lipid-anchor; cytoplasmic side (putative)

Alternative splicing

named isoforms=2

More general terms

• rho subfamily protein

Additional terms

• activated CDC42 kinase 1; ACK-1; tyrosine kinase non-receptor protein 2 (TNK2, ACK1)
• CDC42 homolog; cell division control protein 42 homolog; G25K GTP-binding protein (CDC42)
• CRIB domain (Cdc42/Rac interactive binding domain)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=998
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:998
• OMIM: https://mirror.omim.org/entry/116952
• UniProt: http://www.uniprot.org/uniprot/P60953.html