CDC42 small effector protein 1 (small effector of CDC42 protein 1, CDC42-binding protein SCIP1, CDC42SE1, SPEC1)
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Function
- probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly
- alters CDC42-induced cell shape changes
- in activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse
- may play a role in early contractile events in phagocytosis in macrophages
- interacts with CDC42 (in GTP-bound form)
- interacts weakly with RAC1 & not at all with RHOA
Structure
- CRIB domain mediates interaction with CDC42
- belongs to the CDC42SE/SPEC family
- contains 1 CRIB domain
Compartment
- cytoplasm, cell membrane, lipid-anchor
- recruited to the activated TCR prior actin polymerization
Alternative splicing
named isoforms=2
Expression
- widely expressed
- expressed at higher level in T-lymphocytes, dendritic cells