rac1 proto-oncogene protein; Ras-related C3 botulinum toxin substrate 1; p21-Rac1; Ras-like protein TC25; cell migration-inducing gene 5 protein (RAC1)

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Function

Structure

  • the effector region mediates interaction with DEF6
  • belongs to the small GTPase superfamily, Rho family

Compartment

Alternative splicing

named isoforms=2; Rac1A, Rac1B

Expression

Pathology

  • expression of isoform B is elevated in colorectal tumors at various stages of neoplastic progression

More general terms

References

  1. UniProt http://www.uniprot.org/uniprot/P63000.html
  2. NIEHS-SNPs http://egp.gs.washington.edu/data/rac1/
  3. Kahn RA, Der CJ, Bokoch GM. The ras superfamily of GTP-binding proteins: guidelines on nomenclature. FASEB J. 1992 May;6(8):2512-3. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1592203
  4. Segal AW, Abo A. The biochemical basis of the NADPH oxidase of phagocytes. Trends Biochem Sci. 1993 Feb;18(2):43-7. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8488557
  5. Manser E, Leung T, Salihuddin H, Zhao ZS, Lim L. A brain serine/threonine protein kinase activated by Cdc42 and Rac1. Nature. 1994 Jan 6;367(6458):40-6. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8107774

Database