dedicator of cytokinesis protein2 (DOCK2, KIAA0209)

Function

• cytoskeletal rearrangements for lymphocyte migration in response of chemokines
• guanine nucleotide exchange factor (GEF), exchanges bound GDP for free GTP (putative)
  • activates RAC1 & RAC2 small GTPases guanine
• IL2 transcriptional activation via activation of RAC2
• interacts with RAC1, RAC2, CRKL, VAV, CD3Z

Structure

• the DHR-2 domain may mediate the GEF activity
• belongs to the DOCK family
• contains 1 DHR-1 (CZH-1) domain
• contains 1 DHR-2 (CZH-2) domain
• contains 1 SH3 domain

Compartment

• endomembrane, peripheral membrane
• cytoplasm, cytoskeleton
• colocalizes with F-actin

Alternative splicing

• named isoforms=2
• splicing donor & acceptor sites between exon 6 & exon 7 are not canonical

Expression

• specifically expressed in hematopoietic cells, peripheral blood leukocytes > thymus, spleen > small intestine, colon

More general terms

• dedicator of cytokinesis protein (DOCK)
• phosphoprotein
• human longevity protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1794
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1794
• OMIM: https://mirror.omim.org/entry/603122
• UniProt: http://www.uniprot.org/uniprot/Q92608.html