chemokine; chemoattractant
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Introduction
class of cytokines
* see Figure: CC ligand & receptor binding
* see Figure: CXC ligand & receptor binding
Function
- attract & activate leukocytes
- other functions:
- hematopoietic/lymphopoietic system
- regulation of stem cell maturation
- formation of secondary lymphoid tissues
- angiogenesis
- control of organogenesis
- participate in development of cerebellum & hippocampus
- maturation and migration of stem cells
- role in neuroinflammatory disorders
- role in guiding inflammatory cells to sites of inflammation in the brain
- hematopoietic/lymphopoietic system
More general terms
More specific terms
- C chemokine
- CC chemokine; beta chemokine
- chemokine like factor super family member
- CX3C or CXXXC chemokine
- CXC chemokine; alpha chemokine
Additional terms
References
- ↑ Baggiolini M et al. Interleukin-8 and related chemotactic cytokines--CXC and CC chemokines. Adv Immunol 55:97-179 1994 PMID: https://www.ncbi.nlm.nih.gov/pubmed/8304236
- ↑ Tran PB & Miller RJ. Chemokine receptors: signposts to brain development and disease. Nature Reviews Neuroscience 4:444-455, 2003 PMID: https://www.ncbi.nlm.nih.gov/pubmed/12778117
- ↑ Abbadie C, Bhangoo S, De Koninck Y et al Chemokines and pain mechanisms. Brain Res Rev. 2009 Apr;60(1):125-34 PMID: https://www.ncbi.nlm.nih.gov/pubmed/19146875