hematopoiesis
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Introduction
The formation & development of blood cells, including:
In adults, hematopoiesis is restricted to the pelvis, sternum & vertebrae.
Physiology
- hematopoiesis in adults <65 years of age is massively polyclonal[2]
- in adults >75 years, 30-60% of haematopoiesis is accounted for by 12-18 independent clones, each contributing 1-34% of blood production[2]
- most clones had begun their expansion before age 40 years
- loss of the Y chromosome confers a selective benefits in males
More general terms
More specific terms
- erythropoiesis
- leukocyte differentiation
- leukopoiesis
- megakaryocytopoiesis
- thrombopoiesis; thrombocytopoiesis
Additional terms
References
- ↑ Stedman's Medical Dictionary 27th ed, Williams & Wilkins, Baltimore, 1999
- ↑ 2.0 2.1 2.2 Mitchell E, Spencer Chapman M, Williams N et al. Clonal dynamics of haematopoiesis across the human lifespan. Nature 2022. 606, 343-350 PMID: https://www.ncbi.nlm.nih.gov/pubmed/35650442 PMCID: PMC9177428 Free PMC article https://www.nature.com/articles/s41586-022-04786-y