CD247; T-cell surface glycoprotein CD3 zeta chain; T-cell receptor T3 zeta chain (CD3Z, T3Z, TCRZ)

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Function

Structure

  • belongs to the CD3Z/FCER1G family
  • contains 3 ITAM domains
  • the ITAM domains mediate interaction with SHB

Compartment

membrane

Alternative splicing

named isoforms=2

Pathology

More general terms

Component of

References

  1. UniProt http://www.uniprot.org/uniprot/P20963.html
  2. CD247base; Note: CD247 mutation db http://bioinf.uta.fi/CD247base/
  3. Altman A, Coggeshall KM, Mustelin T. Molecular events mediating T cell activation. Adv Immunol. 1990;48:227-360. Review. No abstract available. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1693465
  4. Bolen JB, Rowley RB, Spana C, Tsygankov AY. The Src family of tyrosine protein kinases in hemopoietic signal transduction. FASEB J. 1992 Dec;6(15):3403-9. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1281458

Database