CD247; T-cell surface glycoprotein CD3 zeta chain; T-cell receptor T3 zeta chain (CD3Z, T3Z, TCRZ)
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Function
- probable role in assembly & expression of the TCR complex as well as signal transduction upon antigen triggering
- associates with/activates fyn
- interacts with SLA & SLA2
- interacts with DOCK2 & TRAT1
- interacts with SHB
- phosphorylated on Tyr after T-cell receptor triggering (putative)
Structure
- belongs to the CD3Z/FCER1G family
- contains 3 ITAM domains
- the ITAM domains mediate interaction with SHB
Compartment
membrane
Alternative splicing
named isoforms=2
Pathology
- defects in CD247 are a cause of primary T-cell immunodeficiency
- interacts with HIV-1 Nef protein
More general terms
Component of
References
- ↑ UniProt http://www.uniprot.org/uniprot/P20963.html
- ↑ CD247base; Note: CD247 mutation db http://bioinf.uta.fi/CD247base/
- ↑ Altman A, Coggeshall KM, Mustelin T. Molecular events mediating T cell activation. Adv Immunol. 1990;48:227-360. Review. No abstract available. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1693465
- ↑ Bolen JB, Rowley RB, Spana C, Tsygankov AY. The Src family of tyrosine protein kinases in hemopoietic signal transduction. FASEB J. 1992 Dec;6(15):3403-9. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1281458