human immunodeficiency virus-1 (HIV-1)
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Introduction
see HIV1 infection
Pathology
- RNA virus encoding a reverse transcriptase, with subsequent insertion of nascent DNA into cellular genome, thus causing latent & persistent infection.
Genetics
- new subtype, Group M, subtype L
- highly virulent subtype B (VB)*[2]
- HIV1 RNA levels 0.5-0.7 log10 higher than non-VB HIV1[2]
* virulence established by HIV1 RNA levels within 6-24 months of a first positive test & rate of CD4 count decline
More general terms
More specific terms
Additional terms
References
- ↑ Yamaguchi J, McArthur C; Vallari A et al Complete genome sequence of CG-0018a-01 establishes HIV-1 subtype L. J Acquir Immune Defic Syndr. 2019 Nov 6 PMID: https://www.ncbi.nlm.nih.gov/pubmed/31693506 https://journals.lww.com/jaids/Abstract/publishahead/Complete_genome_sequence_of_CG_0018a_01.96307.aspx#pdf-link
- ↑ 2.0 2.1 2.2 Wymant C, Bezemer D, Blanquart F et al. A highly virulent variant of HIV-1 circulating in the Netherlands. Science 2022 Feb 3; 375:540 PMID: https://www.ncbi.nlm.nih.gov/pubmed/35113714 https://www.science.org/doi/10.1126/science.abk1688