proto-oncogene tyrosine-protein kinase Fyn; p59-Fyn; protooncogene syn; SLK (FYN)

Function

• implicated in the control of cell growth
• plays a role in regulation of intracellular Ca+2
• isoform 2 shows greater ability to mobilize cytoplasmic Ca+2 in comparison to isoform 1
• required in brain development & mature brain function
• role in regulation of axon growth, axon guidance, & neurite extension
• blocks axon outgrowth & attraction induced by NTN1 by phosphorylating its receptor DDC
• associates through its SH3 domain, to the p85 subunit of phosphatidylinositol 3-kinase.
• interacts with the FYN-binding protein (FYB)
• interacts with phosphorylated TOM1L1
• interacts with CD79A upon activation of the B-cell antigen receptor which increases FYN activity (putative)
• interacts with PAG1
• interacts with SH2D1A & SLAMF1
• interacts (via SH3 domain) with HEV ORF3 protein
• inhibited by phosphorylation of Tyr-531 by leukocyte common antigen & activated by dephosphorylation of this site ,

Cofactor: Mn+2

Structure

• belongs to the protein kinase superfamily, Tyr protein kinase family, SRC subfamily
• contains 1 protein kinase domain
• contains 1 SH2 domain
• contains 1 SH3 domain

Compartment

• cell membrane
• present & active in lipid rafts
• present in cell body & along the process of mature & developing oligodendroyctes

Alternative splicing

named isoforms=3

Expression

• isoform 1 is highly expressed in the brain,
• isoform 2 is expressed in cells of hemopoietic lineages, especially T lymphocytes

More general terms

• src proto-oncogene protein family

Additional terms

• CD28; T-cell-specific surface glycoprotein CD28; TP44
• T-cell receptor/CD3 complex

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2534
• OMIM: https://mirror.omim.org/entry/137025
• UniProt: http://www.uniprot.org/uniprot/P06241.html