CD28; T-cell-specific surface glycoprotein CD28; TP44
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Function
- CD28 binds to & is activated by B-7 (CD80), an Ig-like protein on the surface of antigen-presenting cells
- the interaction of CD28 with B-7 is necessary in addition to stimulation of the T-cell receptor for production of IL-2 in quiescent T-cells
- CD28 associates with & activates lck & fyn[2]
- Tyr-173 phosphorylation allows recruitment of signalling proteins including phosphatidylinositol-3-kinase, GRB2 & GRAP2 through SH2 domains
- interacts with DUSP14
- binds to CD80 (B-7) & CD86
Structure
- homodimer; disulfide-linked.
- contains 1 Ig-like V-type domain (immunoglobulin-like)
Compartment
membrane
Alternative splicing
named isoforms=6
Expression
- CD4+ T cells ~95%
- CD8+ T cells ~50%
- activated B cells
- plasma cells
More general terms
References
- ↑ Turka LA, Ledbetter JA, Lee K, June CH, Thompson CB. CD28 is an inducible T cell surface antigen that transduces a proliferative signal in CD3+ mature thymocytes. J Immunol. 1990 Mar 1;144(5):1646-53. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2155264
- ↑ 2.0 2.1 Bolen JB, Rowley RB, Spana C, Tsygankov AY. The Src family of tyrosine protein kinases in hemopoietic signal transduction. FASEB J. 1992 Dec;6(15):3403-9. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1281458
- ↑ Pawson T Protein modules and signalling networks Nature 373:573 1995 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/7531822
- ↑ <Internet> http://www.pathologyoutlines.com/cdmarkers.html 15 October 2002
- ↑ Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=940
- ↑ Wikipedia; Note: CD28 entry http://en.wikipedia.org/wiki/CD28
- ↑ UniProt http://www.uniprot.org/uniprot/P10747.html