GRB2-related adapter protein 2; protein GADS; growth factor receptor-binding protein; GRBLG; Grf40 adapter protein; Grf-40; GRB-2-like protein; GRB2L; GRBX; P38; hematopoietic cell-associated adapter protein GrpL; adapter protein GRID; SH3-SH2-SH3 adapter mona (GRAP2, GADS, GRB2L, GRID)

Function

• interacts with SLP-76 to regulate NF-AT activation
• binds to Tyr-phosphorylated shc
• interacts with phosphorylated LIME1 upon TCR activation (putative)
• interacts with phosphorylated LAT & LAX1 upon TCR activation
• interacts with SHB

Structure

• belongs to the GRB2/sem-5/DRK family
• contains 1 SH2 domain
• contains 2 SH3 domains

More general terms

• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9402
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9402
• OMIM: https://mirror.omim.org/entry/604518
• UniProt: http://www.uniprot.org/uniprot/O75791.html