lymphocyte transmembrane adapter 1; membrane-associated adapter protein LAX; linker for activation of X cells (LAX1, LAX)

Function

• negatively regulates TCR-mediated signaling in T-cells & BCR-mediated signaling in B-cells
• phosphorylated on Tyr by Syk, Lck or ZAP70 upon TCR or BCR activation
• phosphorylation leads to activation & recruitment of GRB2, PIK3R1 & GRAP2

Compartment

• cell membrane; single pass type 3 membrane protein

Alternative splicing

named isoforms=3

Expression

• expressed in spleen, thymus, peripheral blood leukocytes
• expressed in several B-, T-, NK, monocyte cell lines
• up-regulated in T-cells following TCR engagement

More general terms

• phosphoprotein
• membrane protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=54900
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:54900
• UniProt: http://www.uniprot.org/uniprot/Q8IWV1.html