homeobox protein Nkx-6.1; homeobox protein NK-6 homolog A (NKX6-1, NKX6A)

Function

• transcription factor which binds to specific A/T-rich DNA sequences in the promoter regions of a number of genes involved in transcriptional regulation in islet beta cells
• binds to the insulin promoter & is involved in regulation of the insulin gene
• together with NKX2-2 & IRX3 acts to restrict the generation of motor neurons to the appropriate region of the neural tube
• belongs to class II proteins of neuronal progenitor factors, which are induced by SHH signals

Structure

• the C-terminal domain contributes to sequence-specific DNA-binding (putative)
• contains 1 homeobox DNA-binding domain

Compartment

nucleus (probable)

Expression

pancreatic beta cells

More general terms

• homeobox protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4825
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4825
• OMIM: https://mirror.omim.org/entry/602563
• UniProt: http://www.uniprot.org/uniprot/P78426.html