homeobox protein Nkx-2.2; homeobox protein NK-2 homolog B (NKX2-2, NKX22, NKX2B)

Function

• acts as a transcriptional activator
• required for the maintenance of NEUROD1 expression in the horomone-producing endocrine cells of the pancreas
• may be involved in specifying diencephalic neuromeric boundaries, & in controlling expression of genes that play a role in axonal guidance
• associates with chromatin at the NEUROD1 promoter region
• binds to a subset of consensus elements within the NEUROD1 promoter
• interacts with OLIG2 (putative)

Structure

• the homeodomain is essential for interaction with OLIG2 belongs to the NK-2 homeobox family
• contains 1 homeobox DNA-binding domain

Compartment

nucleus (putative)

More general terms

• homeobox protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4821
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4821
• OMIM: https://mirror.omim.org/entry/604612
• UniProt: http://www.uniprot.org/uniprot/O95096.html