iroquois-class homeodomain protein IRX-3; homeodomain protein IRXB1; iroquois homeobox protein 3 (IRX3, IRXB1)

Function

• transcription factor
• involved in SHH-dependent neural patterning
• together with NKX2-2 & NKX6-1, acts to restrict the generation of motor neurons to the appropriate region of the neural tube
• belongs to the class I proteins of neuronal progenitor factors, which are repressed by SHH signals
• involved in the transcriptional repression of MNX1 in non-motor neuron cells (putative)

Structure

• belongs to the TALE/IRO homeobox family
• contains 1 homeobox DNA-binding domain

Compartment

nucleus (probable)

More general terms

• Iroquois-class homeodomain protein IRX

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=79191
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:79191
• OMIM: https://mirror.omim.org/entry/612985
• UniProt: http://www.uniprot.org/uniprot/P78415.html