breakpoint cluster region protein P160 (p160BCR)

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Introduction

Protein product of BCR-gene (breakpoint cluster region) gene that forms a chimeric gene with abl in the Philadelphia chromosome associated with chronic myelogenous leukemia (CML).

Function

ATP + a protein <--> ADP + a phosphoprotein

Structure

Alternative splicing

named isoforms=2

Pathology

More general terms

More specific terms

Additional terms

References

  1. Maru Y, Witte ON. The BCR gene encodes a novel serine/threonine kinase activity within a single exon. Cell. 1991 Nov 1;67(3):459-68. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1657398
  2. Musacchio A, Gibson T, Rice P, Thompson J, Saraste M. The PH domain: a common piece in the structural patchwork of signalling proteins. Trends Biochem Sci. 1993 Sep;18(9):343-8. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8236453
  3. Atlas of Genetics & cytogenetics in oncology & Haematology http://atlasgeneticsoncology.org/Genes/BCR.html

Database