pleckstrin homology [PH] domain
Jump to navigation
Jump to search
Introduction
A group of related sequences 50-100 amino acids in length. PH-domains may be involved in interactions with the beta/gamma subunits of GTP-binding proteins &/or they may associate with phospholipids & promote association of signaling proteins with membranes. Proteins containing a PH-domain are generally cytoplasmic, but associate with the plasma membrane.
PH-domains are comprised of 2 roughly perpendicular anti-parallel beta sheets, followed by a C-terminal amphipathic alpha-helix.
More general terms
Additional terms
References
- ↑ Musacchio A, Gibson T, Rice P, Thompson J, Saraste M. The PH domain: a common piece in the structural patchwork of signalling proteins. Trends Biochem Sci. 1993 Sep;18(9):343-8. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8236453
- ↑ Pawson T Protein modules and signalling networks Nature 373:573 1995 (Notch) PMID: https://www.ncbi.nlm.nih.gov/pubmed/7531822