PDZ domain-containing protein 1 (CFTR-associated protein of 70 kD, Na+/Pi cotransporter C-terminal-associated protein, Na+Pi-Cap1, Na+/H+ exchanger regulatory factor 3, C-terminal linking & modulating protein, CLAMP, PDZK1, CAP70, NHERF3, PDZD1)
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Function
- scaffold protein, connects plasma membrane proteins with regulatory components
- regulates surface expression of plasma membrane proteins in epithelial cells apical domains
- ion transport & second messenger cascades
- forms complex with SLC9A3R1
- clusters proteins, modulates trafficking & activity of associated membrane proteins
- multidrug resistance via interaction with ABCC2 & PDZK1IP1
- potentiates CFTR chloride channel activity (putative)
- intracellular cholesterol transport &/or metabolism via SCARB1 (putative)
- regulation of proximal tubular Na+-dependent inorganic phosphate cotransport
- interacts with PDZK1IP1 & ABCC2
- binds to the C-terminal region of SLC26A3
- interacts via 1ST PDZ domain with C-terminal domain of SCARB1
- interacts with AKAP2, BCR, CFTR, SLCO1A1, SLC22A12, SLC22A4, SLC22A5, SLC26A6, SLC9A3R2, SLC17A1 (putative)
Compartment
- cytoplasm, peripheral membrane
- apical compartment of proximal tubular cells
- sinusoidal liver membranes
Expression
- limited to epithelial cells
- expressed in the kidney (brush border of proximal tubule), pancreas, liver, small intestine > adrenal cortex, testis, stomach
Pathology
- overexpressed in breast carcinoma, renal carcinoma, lung carcinoma
More general terms
Additional terms
- cystic fibrosis transmembrane conductance regulator; CFTR; cAMP-dependent chloride channel; ATP-binding cassette transporter sub-family C member 7 (CFTR ABCC7)
- PDZ (PSD-95 post-synaptic density protein, Discs large, Zona occludens tight junction protein) domain
- PDZ domain-containing protein