Cl- channel
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Introduction
- chloride channels have several functions including
- regulation of cell volume
- membrane potential stabilization
- signal transduction
- transepithelial transport
Structure
- the CLC channel family contains both chloride channels & proton-coupled anion transporters that exchange chloride or another anion for protons
- the absence of conserved gating Glu is typical for family members that function as channels (putative)
More general terms
More specific terms
- anion exchange protein 3 (neuronal band 3-like protein, cardiac/brain band 3-like protein, CAE3/BAE3, solute carrier family 4 member 3, SLC4A3, SLC2, AE3)
- anoctamin-1; transmembrane protein 16A; discovered on gastrointestinal stromal tumors protein 1; oral cancer overexpressed protein 2; tumor amplified & overexpressed sequence 2 (TMEM16A, DOG1, ORAOV2, TAOS2, ANO1)
- band 3 anion transport protein; anion exchange protein 1; anion exchanger 1; AE 1; solute carrier family 4 member 1; CD233 (SLC4A1, AE1, DI, EPB3)
- band 3-related protein; anion exchange protein 2; anion exchanger 2; AE 2; non-erythroid band 3-like protein; BND3L; solute carrier family 4 member 2 (SLC4A2, AE2 ,EPB3L1, HKB3, MPB3L)
- brain-derived voltage-dependent anion channel-1
- Ca+2-dependent Cl- channel
- chloride channel protein 2; ClC-2 (CLCN2)
- chloride channel protein 3; H+/Cl(-) exchange transporter 3; chloride transporter ClC-3; ClC-3 (CLCN3)
- chloride channel protein 4; H+/Cl- exchange transporter 4; chloride transporter ClC-4; ClC-4 (CLCN4)
- chloride channel protein ClC-Ka; chloride channel Ka; ClC-K1 (CLCNKA)
- chloride channel protein ClC-Kb; chloride channel Kb; ClC-K2 (CLCNKB)
- chloride channel protein-1; chloride channel protein, skeletal muscle; ClC-1 (CLCN1, CLC1)
- chloride transport protein 6; chloride channel protein 6; ClC-6 (CLCN6 KIAA0046)
- Cl- channel CLIC-like protein 1 (mid-1-related chloride channel protein 1, CLCC1, KIAA076, MCLC)
- cystic fibrosis transmembrane conductance regulator; CFTR; cAMP-dependent chloride channel; ATP-binding cassette transporter sub-family C member 7 (CFTR ABCC7)
- GABA-A receptor
- glycine receptor
- H+/Cl(-) exchange transporter 5; chloride transporter ClC-5; chloride channel protein 5; ClC-5 (CLCN5, CLCK2, NPHL2, DENTS)
- H+/Cl- exchange transporter 7; chloride channel protein 7; ClC-7 (CLCN7)
- stilbene-sensitive Cl- channel
- voltage-dependent anion-selective channel protein 1; VDAC-1; hVDAC1; outer mitochondrial membrane protein porin 1; plasmalemmal porin; porin 31HL; porin 31HM (VDAC1 VDAC)