chloride channel protein ClC-Ka; chloride channel Ka; ClC-K1 (CLCNKA)

Function

• voltage-gated chloride channel
• chloride channels have several functions including
  • regulation of cell volume
  • membrane potential stabilization
  • signal transduction
  • transepithelial transport
• may be important in urinary concentrating mechanisms
• interacts with barttin (BSND)
• forms heteromers with BSND in the thin ascending limb of Henle (putative)

Structure

• belongs to the chloride channel (TC 2.A.49) family
• contains 2 CBS domains

Compartment

membrane

Expression

• expressed predominantly in the kidney
• all nephron segments expressing barttin (BSND) also express CLCNK proreins

More general terms

• Cl- channel
• phosphoprotein
• transmembrane 10 protein

Database

• UniProt: http://www.uniprot.org/uniprot/P51800.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1187
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1187
• OMIM: https://mirror.omim.org/entry/602024