glycine receptor
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Function
- neurotransmitter-gated ion channel
- binding of glycine to its receptor increases the chloride conductance, thus produces hyperpolarization (inhibition of neuronal firing)
- associates with 93 kD cytoplasmic protein
Structure
- pentamer composed of alpha & beta subunits
Compartment
membrane
Alternative splicing
named isoforms=2
Expression
widely distributed throughout central nervous system
Pathology
- alpha subunit binds strychnine
More general terms
Additional terms
References
- ↑ Grenningloh G, Pribilla I, Prior P, Multhaup G, Beyreuther K, Taleb O, Betz H. Cloning and expression of the 58 kd beta subunit of the inhibitory glycine receptor. Neuron. 1990 Jun;4(6):963-70. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2163264 [PubMed - indexed for MEDLINE]
- ↑ Grenningloh G, Schmieden V, Schofield PR, Seeburg PH, Siddique T, Mohandas TK, Becker CM, Betz H. Alpha subunit variants of the human glycine receptor: primary structures, functional expression and chromosomal localization of the corresponding genes. EMBO J. 1990 Mar;9(3):771-6. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2155780
- ↑ Barnard EA. Receptor classes and the transmitter-gated ion channels. Trends Biochem Sci. 1992 Oct;17(10):368-74. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1360717