anion exchange protein 3 (neuronal band 3-like protein, cardiac/brain band 3-like protein, CAE3/BAE3, solute carrier family 4 member 3, SLC4A3, SLC2, AE3)

Function

• plasma membrane anion exchange protein of wide distribution
• mediates at least a part of the Cl-/HCO3- exchange in cardiac myocytes
• both isoforms BAE3 & CAE3 transport Cl-

Structure

belongs to the anion exchanger (TC 2.A.31) family

Compartment

membrane

Alternative splicing

named isoforms=2, BAE3, CAE3

Additional isoforms seem to exist

Expression

• both BAE3 & CAE3 isoforms are expressed in failing ventricle

Laboratory

• anion exchange protein 3 Ag in tissue

More general terms

• anion exchange protein
• Cl- channel
• plasma membrane protein
• glycoprotein
• solute carrier family 4 (SLC4, SLC4A)

Database

• OMIM: https://mirror.omim.org/entry/106195
• UniProt: http://www.uniprot.org/uniprot/P48751.html