chloride channel protein 4; H+/Cl- exchange transporter 4; chloride transporter ClC-4; ClC-4 (CLCN4)

Function

• proton-coupled chloride transporter
• functions as antiport system & exchanges Cl- against H+

Structure

• belongs to the chloride channel (TC 2.A.49) family
• contains 2 CBS domains
• presence of conserved gating Glu is typical for chloride channel family members that function as antiporters

Compartment

• multi-pass membrane protein
• early endosome membrane, late endosome membrane

Expression

• abundant in skeletal muscle
• also detectable in brain & heart

More general terms

• Cl- channel
• transmembrane 10 protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1183
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1183
• OMIM: https://mirror.omim.org/entry/302910
• UniProt: http://www.uniprot.org/uniprot/P51793.html