solute carrier family 12 member 2; bumetanide-sensitive Na+/K+/Cl- cotransporter 1; basolateral Na+/K+/Cl- symporter (SLC12A2, NKCC1)

Function

• electrically silent transporter system
• mediates Na+ & Cl- reabsorption
• role in regulation of ionic balance & cell volume
• phosphorylated upon DNA damage, probably by ATM or ATR

Structure

belongs to the SLC12A transporter family

Compartment

membrane

Alternative splicing

named isoforms=2

Expression

expressed in many tissues

More general terms

• transmembrane 12 protein
• solute carrier family 12 (SLC12, SLC12A)
• phosphoprotein
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6558
• OMIM: https://mirror.omim.org/entry/600840
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6558
• UniProt: http://www.uniprot.org/uniprot/P55011.html