chloride transport protein 6; chloride channel protein 6; ClC-6 (CLCN6 KIAA0046)

Function

• chloride transport protein
• initially identified as voltage-gated chloride channel
• the presence of the conserved gating Glu suggests that it functions as antiporter

Structure

• N-glycosylated on several asparagine residues
• belongs to the chloride channel (TC 2.A.49) family
• contains 2 CBS domains

Compartment

• endosome membrane; multi-pass membrane protein
• detected in detergent-resistant lipid rafts

Alternative splicing

named isoforms=5; A-E

Expression

• testis, ovary, small intestine, brain & skeletal muscle
• low level expression in aortic & coronary vascular smooth muscle cells, & aortic endothelial cells
• isoform C is only detected in kidney

Notes

• the CLC channel family contains both chloride channels & proton-coupled anion transporters that exchange chloride or another anion for protons
• the presence of conserved gating Glu is typical for family members that function as antiporters (putative)

More general terms

• Cl- channel
• glycoprotein
• transmembrane 10 protein

Database

• UniProt: http://www.uniprot.org/uniprot/P51797.html