lipid rafts; detergent-insoluble glycolipid-rich domains (DIGs); glycolipid-enriched membranes (GEMs); low-density Triton-insoluble (LDTI) complexes

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Introduction

Cholesterol-rich microdomains in the exoplasmic leaflet of the membrane bilayer. Plasma membrane lipid rafts consist of clusters of about 20 proteins & ~3500 sphingolipid molecules. They are about 50 nm in diameter, but may aggregate into the um range by receptor activation or bivalent antibodies against raft- associated surface antigens. Lipid rafts may also occur in the GOLGI.

Function

Constituents

* substrate (APP#) & enzymes (APP gamma-secretase & BACE1) present in neuronal lipid rafts. beta-Peptide (dimers) may accumulate in neuronal lipid rafts in mouse-model for Alzheimer's disease. apoE & phosphorylated tau found associated with the lipid rafts after appearance of beta-peptide.[5]

# most APP is not within lipid rafts

More general terms

More specific terms

Additional terms

References

  1. Galbiati et al, Cell 106:403, 2001 PMID: https://www.ncbi.nlm.nih.gov/pubmed/11525727
  2. Simon & Toomre, Nature Reviews 1:31, 2000 PMID: https://www.ncbi.nlm.nih.gov/pubmed/11413487
  3. Marx J. Science 294:1862, 2001
  4. Nebl T et al, JBC 277(45):43399 2002 PMID: https://www.ncbi.nlm.nih.gov/pubmed/12202484
  5. 5.0 5.1 5.2 Kawarabayashi T et al, J Neurosci 24(15):3801, 2004 PMID: https://www.ncbi.nlm.nih.gov/pubmed/15084661