vesicular integral-membrane protein VIP36; glycoprotein GP36b; lectin mannose-binding 2; vesicular integral-membrane protein 36; VIP36 (LMAN2, C5orf8)

Function

• intracellular lectin in the early secretory pathway
• role in transport & sorting of glycoproteins carrying high mannose-type glycans
• interacts with:
  • N-acetyl-D-galactosamine
  • high-mannose glycans
  • O-linked glycans (possibly)

Cofactor: binds 2 Ca+2 per subunit

Structure

• contains 1 L-type lectin-like domain

Compartment

• endoplasmic reticulum, Golgi
• type 1 membrane protein

Expression

ubiquitous

More general terms

• glycoprotein
• membrane protein
• Ca+2 binding protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10960
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10960
• OMIM: https://mirror.omim.org/entry/609551
• UniProt: http://www.uniprot.org/uniprot/Q12907.html