epidermal growth factor receptor; receptor tyrosine-protein kinase ErbB-1 (EGFR, ERBB1, HER1)

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Function

Structure

Compartment

Alternative splicing

named isoforms=4

Expression

Pathology

More general terms

Additional terms

References

  1. UniProt http://www.uniprot.org/uniprot/P00533.html
  2. GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=EGFR
  3. Wikipedia; Note: EGFR entry http://en.wikipedia.org/wiki/epidermal_growth_factor_receptor
  4. Nishibe S et al Selectivity of phospholipase C phosphorylation by the epidermal growth factor receptor, the insulin receptor, and their cytoplasmic domains. Proc Natl Acad Sci U S A. 1990 Jan;87(1):424-8. Erratum in: Proc Natl Acad Sci U S A 1990 Apr;87(8):3253. Kim JJ [corrected to Kim JW]. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2153302
  5. Wang KK et al Calmodulin-binding proteins as calpain substrates. Biochem J 262:693 1989 PMID: https://www.ncbi.nlm.nih.gov/pubmed/2556106
  6. Hollenberg MD. Structure-activity relationships for transmembrane signaling: the receptor's turn. FASEB J. 1991 Feb;5(2):178-86. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1848518
  7. Harrison's Principles of Internal Medicine, 13th ed. Isselbacher et al (eds), McGraw-Hill Inc. NY, 1994, pg 769
  8. Pawson T Protein modules and signalling networks Nature 373:573 1995 PMID: https://www.ncbi.nlm.nih.gov/pubmed/7531822
  9. Kemp BE, Pearson RB. Protein kinase recognition sequence motifs. Trends Biochem Sci. 1990 Sep;15(9):342-6. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2238044

Patient information

epidermal growth factor [EGF] receptor patient information

Database