EGF receptor family protein or erbB proto-oncogene protein
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Introduction
Ligand binding induces homo- & hetero-dimerization of receptors & activation of intrinsic kinase domain resulting in autophosphorylation on cytoplasmic tail.
More general terms
More specific terms
- epidermal growth factor receptor; receptor tyrosine-protein kinase ErbB-1 (EGFR, ERBB1, HER1)
- receptor tyrosine-protein kinase erbB-2; p185erbB2; C-erbB-2; NEU proto-oncogene; tyrosine kinase-type cell surface receptor HER2; MLN 19; CD340 (ERBB2, HER2, NEU, NGL)
- receptor tyrosine-protein kinase erbB-3; c-erbB3; tyrosine kinase-type cell surface receptor HER3 (ERBB3, HER3)
- receptor tyrosine-protein kinase erbB-4; p180erbB4; tyrosine kinase-type cell surface receptor HER4 (ERBB4, HER4)