tyrosine kinase receptor (RTK)

Introduction

After growth factor binding, RTKs dimerize, autophosphorylate & recruit adaptor proteins which interact with & activate various downstream effectors.

* see figure

More general terms

• tyrosine kinase (protein tyrosine kinase, PTK)
• cell surface receptor

More specific terms

• ALK tyrosine kinase receptor; anaplastic lymphoma kinase; CD246 (ALK)
• angiopoietin-1 receptor; tyrosine-protein kinase receptor TIE-2; hTIE2; tyrosine-protein kinase receptor TEK; tunica interna endothelial cell kinase; p140 TEK; CD202b (TEK, TIE2)
• c-kit protein; mast/stem cell growth factor receptor; SCFR; proto-oncogene tyrosine-protein kinase Kit; c-kit; CD117 (KIT)
• discoidin domain-containing receptor 2; discoidin domain receptor 2; receptor protein-tyrosine kinase TKT; tyrosine-protein kinase TYRO10; neurotrophic tyrosine kinase, receptor-related 3; CD167 antigen-like family member B; CD167b (DDR2, NTRKR3, TKT, ...
• EGF receptor family protein or erbB proto-oncogene protein
• elk receptor or Cek5 receptor
• eph family receptor
• epithelial discoidin domain-containing receptor 1; epithelial discoidin domain receptor 1; tyrosine kinase DDR; discoidin receptor tyrosine kinase; tyrosine-protein kinase CAK; cell adhesion kinase; TRK E; protein-tyrosine kinase RTK 6; HGK2; CD167 ant...
• eyk proto-oncogene receptor tyrosine kinase (chicken)
• fetal liver kinase-2 (flk-2)
• fibroblast growth factor [FGF] receptor
• FL cytokine receptor; tyrosine-protein kinase receptor FLT3; stem cell tyrosine kinase 1; STK-1; CD135 (FLT3, STK1)
• fms receptor
• hepatocyte growth factor receptor; HGF receptor; scatter factor receptor; SF receptor; HGF/SF receptor; Met proto-oncogene tyrosine kinase; c-Met (MET)
• insulin receptor-related protein; IR-related receptor; contains: insulin receptor-related protein alpha chain & insulin receptor-related protein beta chain (INSRR, IRR)
• insulin receptor; IR; (INSR)
• insulin-like growth factor [IGF]-1 receptor (somatomedin-C receptor, CD221, IGF1R)
• insulin-like growth factor [IGF]-2 receptor (CD222, somatomedin MSA receptor, cation-independent mannose-6-phosphate receptor, MPR 300, CI-MPR, M6PR, MPRI, IGF2R)
• Leukocyte tyrosine kinase receptor; protein tyrosine kinase 1 (LTK, TYK1)
• macrophage-stimulating protein receptor; MSP receptor; p185-Ron; CDw136; CD136 (MST1R, PTK8, RON)
• muscle, skeletal receptor tyrosine protein kinase(muscle-specific tyrosine protein kinase receptor, MuSK)
• neuroepithelial tyrosine kinase or protein tyrosine kinase-3
• platelet-derived growth factor [PDGF] receptor
• preproinsulin receptor; IR; CD220; contains: insulin receptor subunit alpha, insulin receptor subunit beta (INSR)
• proto-oncogene tyrosine-protein kinase MER; C-mer; receptor tyrosine kinase MerTK (MERTK, MER)
• proto-oncogene tyrosine-protein kinase receptor ret; C-ret; (RET, CDHF12)
• proto-oncogene tyrosine-protein kinase ROS; c-ros protein; p53ros; mcf3 tyrosine kinase receptor; c-ros-1 (ROS1)
• RON protein or macrophage stimulating 1 receptor (MST1R)
• sea proto-oncogene protein
• tropomyosin receptor kinase (trk) proto-oncogene protein
• tyrosine-protein kinase ITK/TSK; T-cell-specific kinase; tyrosine-protein kinase Lyk; kinase EMT (ITK, EMT, LYK)
• tyrosine-protein kinase receptor Tie-1 (TIE1, TIE)
• tyrosine-protein kinase receptor TYRO3; tyrosine-protein kinase RSE; tyrosine-protein kinase SKY; tyrosine-protein kinase DTK; tyrosine-protein kinase byk (TYRO3, BYK, DTK, RSE, SKY)
• tyrosine-protein kinase receptor UFO; AXL proto-oncogene protein (AXL, UFO)
• tyrosine-protein kinase RYK (RYK, JTK5A)
• tyrosine-protein kinase transmembrane receptor ROR1; neurotrophic tyrosine kinase, receptor-related 1 (ROR1, NTRKR1)
• tyrosine-protein kinase transmembrane receptor ROR2; neurotrophic tyrosine kinase, receptor-related 2 (ROR2, NTRKR2)
• vascular endothelial growth factor [VEGF] receptor