eph family receptor
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Function
- role in:
- embryonic patterning
- neural development (eg. neural crest cell migration)
- synaptic plasticity (axon pathfinding)/learning & memory
- angiogenesis
- signalling between eph receptors & eph ligands is bidirectional
- binding of eph ligand to eph receptor induces receptor dimerization & trans-phosphorylation of cytoplasmic kinase domains
- phosphorylated Tyr serve as docking sites for proteins including ras-GTPase activating protein, src & abl family proteins, phospholipase C-gamma, PI-3-kinase & adaptor proteins SLAP, grb2, grb10 & nck
Structure
- PDZ binding motif binds PDZ domain containing proteins including AF6, pick 1, syntenin, grip 1 & grip 2
More general terms
More specific terms
References
- ↑ Eph Nomenclature Committee. Cell 90:403-4 1997
- ↑ Cheng N, Brantley DM, Chen J. The ephrins and Eph receptors in angiogenesis. Cytokine Growth Factor Rev. 2002 Feb;13(1):75-85. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11750881