phosphoinositide-3-kinase (phosphatidylinositol-3-kinase, PI3K)

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Function

              PI3K
PIP2  +  ATP   --->   PIP3 +  ADP

* see figure

Pharmacology

More general terms

References

  1. Nolan RD, Lapetina EG. Thrombin stimulates the production of a novel polyphosphoinositide in human platelets. J Biol Chem. 1990 Feb 15;265(5):2441-5. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2154447
  2. Cantley LC, Auger KR, Carpenter C, Duckworth B, Graziani A, Kapeller R, Soltoff S. Oncogenes and signal transduction. Cell. 1991 Jan 25;64(2):281-302. Review. Erratum in: Cell 1991 May 31;65(5):following 914. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1846320
  3. 3.0 3.1 Hu Q, Klippel A, Muslin AJ, Fantl WJ, Williams LT. Ras-dependent induction of cellular responses by constitutively active phosphatidylinositol-3 kinase. Science. 1995 Apr 7;268(5207):100-2. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7701328
  4. 4.0 4.1 4.2 4.3 Yao R, Cooper GM. Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor. Science. 1995 Mar 31;267(5206):2003-6. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7701324
  5. 5.0 5.1 Clark EA & Brugge JS Integrins and signal transduction pathways: the road taken. Science 268:233 1995 PMID: https://www.ncbi.nlm.nih.gov/pubmed/7716514
  6. 6.0 6.1 Gever J, MedPage Today. September 14, 2017 Novel Kinase Inhibitor OK'd for Follicular Lymphoma. Copanlisib (Aliqopa) approved as third-line therapy. https://www.medpagetoday.com/HematologyOncology/Lymphoma/67913

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