elafin; elastase-specific inhibitor; ESI; peptidase inhibitor 3; PI-3; protease inhibitor WAP3; skin-derived antileukoproteinase; SKALP; WAP four-disulfide core domain protein 14 (PI3, WAP3, WFDC14)

Function

• neutrophil & pancreatic elastase-specific inhibitor of skin
• may prevent elastase-mediated tissue proteolysis

Structure

• consists of two domains:
  • the transglutaminase substrate domain (cementoin moiety) serves as an anchor to localize elafin covalently to specific sites on extracellular matrix proteins
  • elastase inhibitor domain
• contains 1 WAP domain

Compartment

secreted

More general terms

• secreted protein
• enzyme inhibitor

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5266
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5266
• OMIM: https://mirror.omim.org/entry/182257
• UniProt: http://www.uniprot.org/uniprot/P19957.html