leukocyte elastase inhibitor; LEI; monocyte/neutrophil elastase inhibitor; M/NEI; EI; serpin B1 (SERPINB1, ELANH2, MNEI, PI2)

Function

• regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, & kallikrein-3

Structure

• reactive bond 1 is specific for reaction with chymotrypsin-like protease such as cathepsin G, chymotrypsin or chymase,
• reactive bond 2 is specific for reaction with elastase-like protease such as neutrophyl elastase, proteinase-3, pancreatic elastase or PSA
• belongs to the serpin family, Ov-serpin subfamily

Compartment

cytoplasm (putative)

More general terms

• serine protease inhibitor; serpin
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1992
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1992
• OMIM: https://mirror.omim.org/entry/130135
• UniProt: http://www.uniprot.org/uniprot/P30740.html