mast cell protease-1; mast cell protease-7; chymase (CMA1, MCP1)

Function

• major secreted protease of mast cells
• suspected roles in vasoactive peptide generation, extracellular matrix degradation, & regulation of gland secretion
• preferential cleavage: Phe-|-Xaa > Tyr-|-Xaa > Trp-|-Xaa > Leu-|-Xaa

Structure

• belongs to the peptidase S1 family, Granzyme subfamily
• contains 1 peptidase S1 domain

Compartment

• secreted, cytoplasmic granul, mast cell granules

Expression

mast cells in lung, heart, skin & placenta

More general terms

• serine protease trypsin family
• secreted protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1215
• OMIM: https://mirror.omim.org/entry/118938
• UniProt: http://www.uniprot.org/uniprot/P23946.html