prostate-specific antigen; PSA; gamma-seminoprotein; seminin; kallikrein-3; P-30 antigen; semenogelase (KLK3 APS)
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Function
- in the seminal fluid, PSA cleaves a seminal vesicle-specific protein into several low-MW proteins as part of the process of liquefaction of the seminal coagulum
- hydrolyzes semenogelin-1 thus leading to the liquefaction of seminal coagulum
- preferential cleavage: -Tyr-|-Xaa-
- inhibited by SERPINA5
- activity is strongly inhibited by Zn2+, 100 times more abundant in semen than in serum
- this inhibition is relieved by exposure to semenogelins, which are avid Zn+2 binders
- forms heterodimer with SERPINA5
Structure
- belongs to the peptidase S1 family, kallikrein subfamily
- contains 1 peptidase S1 domain
Compartment
Expression
- PSA is produced exclusively by epithelial cells of the acini & ducts of the prostate gland & is secreted into the lumena of the prostatic duct
Pathology
- serum prostate-specific antigen may be increased in
More general terms
Additional terms
References
- ↑ Clinical Diagnosis & Management by Laboratory Methods, J.B. Henry (ed), W.B. Saunders Co., Philadelphia, PA. 1991, pg 293
- ↑ Tietz Textbook of Clinical Chemistry, 2nd ed. Burtis CA & Ashwood ER (eds), WB Saunders Co, Philadelphia PA, 1993, pg 907
- ↑ Kaiser Permanente Northern California protocol, 1/2000
- ↑ Medical Knowledge Self Assessment Program (MKSAP) 11, American College of Physicians, Philadelphia 1998
- ↑ Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=354