rho subfamily protein
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Function
- regulation of cytoskeleton assembly (putative)
- essential for serum-induced formation of focal adhesions & stress fibers
- activates PI-3-kinase & PIP-5-kinase (putative)
- may induce tyrosine kinase activity[3]
- role in integrin-mediated cell surface adhesion & proliferation, thus in synapse formation & neuronal plasticity[4]
Pathology
- exoenzyme C3 of C. botulinum ADP-ribosylates rho & disrupts actin microfilaments
More general terms
More specific terms
- CDC42 homolog; cell division control protein 42 homolog; G25K GTP-binding protein (CDC42)
- rac proto-oncogene protein (p21rac)
- Rho-related GTP-binding protein RhoE; Rho family GTPase 3; Rnd3; Rho8; memB protein (RND3, ARHE, RHO8, RHOE)
- Rho-related GTP-binding protein RhoF; Rho family GTPase Rif; Rho in filopodia (RHOF, ARHF, RIF)
- rho6 protein (Rho-related GTP-binding protein Rho6, Rnd1)
- rhoA proto-oncogene protein; transforming protein RhoA; H12 (RHOA, ARH12, ARHA, RHO12)
- rhoB proto-oncogene protein; Rho-related GTP-binding protein RhoB; rho protein H6 (RHOB, ARH6, ARHB)
- rhoC proto-oncogene protein; Rho-related GTP-binding protein RhoC; rho protein H9 (RHOC, ARH9, ARHC)
- rhoD protein; Rho-related GTP-binding protein RhoD; Rho-related protein HP1; RhoHP1 (RHOD, ARHD)
- rhoG proto-oncogene protein, G25K, Gp protein or CDC42Hs
- RhoH protein; Rho-related GTP-binding protein RhoH; GTP-binding protein TTF; translocation three-four (RhoH, ARHH, TTF)
- rhoI protein; GTP-binding protein Di-Ras3; distinct subgroup of the Ras family member 3; Rho-related GTP-binding protein RhoI (DIRAS3, ARHI, NOEY2, RHOI)
- rhoN protein (Rho-related GTP-binding protein RhoN, Rho7, Rnd2)
References
- ↑ Bourne HR et al, The GTPase superfamily: a conserved switch for diverse cell functions Nature 348:125 1990 PMID: https://www.ncbi.nlm.nih.gov/pubmed/2122258
- ↑ Kahn RA, Der CJ, Bokoch GM. The ras superfamily of GTP-binding proteins: guidelines on nomenclature. FASEB J. 1992 May;6(8):2512-3. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1592203
- ↑ 3.0 3.1 Clark EA & Brugge JS Integrins and signal transduction pathways: the road taken. Science 268:233 1995 PMID: https://www.ncbi.nlm.nih.gov/pubmed/7716514
- ↑ 4.0 4.1 Rampon C, Jiang CH, Dong H, Tang YP, Lockhart DJ, Schultz PG, Tsien JZ, Hu Y. Effects of environmental enrichment on gene expression in the brain. Proc Natl Acad Sci U S A. 2000 Nov 7;97(23):12880-4. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11070096