rhoC proto-oncogene protein; Rho-related GTP-binding protein RhoC; rho protein H9 (RHOC, ARH9, ARHC)
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Function
- regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions & actin stress fibers
- interacts with DIAPH1, ROCK1, ROCK2 & RTKN
- interacts with AKAP13
Structure
belongs to the small GTPase superfamily, Rho family
Compartment
- cell membrane; lipid-anchor; cytoplasmic side (putative)
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/P08134.html
- ↑ Atlas of Genetics & Cytogenetics in Oncology & Haematology http://atlasgeneticsoncology.org/genes/RHOCID42110ch1p13.html
- ↑ OMIM https://mirror.omim.org/entry/165390
- ↑ Kahn RA, Der CJ, Bokoch GM. The ras superfamily of GTP-binding proteins: guidelines on nomenclature. FASEB J. 1992 May;6(8):2512-3. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1592203
- ↑ Manser E, Leung T, Salihuddin H, Zhao ZS, Lim L. A brain serine/threonine protein kinase activated by Cdc42 and Rac1. Nature. 1994 Jan 6;367(6458):40-6. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8107774
- ↑ Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=389