rhotekin (RTKN)

Function

• mediates Rho signaling to activate NF-kappa-B
• organization of septin structures
• interacts via its C-terminal region with TAX1BP3 PDZ domain
  • facilitates Rho-mediated activation of c-Fos serum response element (SRE
• interacts with SEPT9
• binds to GTP-bound RHOA, RHOB & RHOC & inhibits their GTPase activity

Alternative splicing

named isoforms=3

Expression

• expressed in prostate > kidney, heart, brain, spleen, testis, placenta, small intestine, pancreas, skeletal muscle, peripheral blood leukocytes > ovary, colon, thymus
• weakly expressed in all normal cell lines

Pathology

• overexpressed in various cancer cell lines
• may confer increased resistance to apoptosis to cells in gastric cancer

More general terms

• guanine nucleotide regulatory protein (GNRP)

Database

• OMIM: https://mirror.omim.org/entry/602288
• UniProt: http://www.uniprot.org/uniprot/Q9BST9.html