rhoA proto-oncogene protein; transforming protein RhoA; H12 (RHOA, ARH12, ARHA, RHO12)
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Function
- implicated in the assembly of focal adhesions & actin stress fibers
- regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions & actin stress fibers
- may be an activator of PLCE1
- activated by ARHGEF2, which promotes the exchange of GDP for GTP
- interacts with RGNEF (putative)
- binds PRKCL1, ROCK1 & ROCK2
- interacts with ARHGEF2, ARHGEF3, NET1 & RTKN
- interacts with PLCE1 & AKAP13
Structure
- basic-rich region is essential for yopT recognition & cleavage
- belongs to the small GTPase superfamily, Rho family
Compartment
- cell membrane; lipid-anchor; cytoplasmic side
- cytoskeleton
Pathology
- serves as a target for the yopT cysteine peptidase from Yersinia pestis & Yersinia pseudotuberculosis
- cleaved by yopT protease when the cell is infected by Yersinia; this removes the lipid attachment, & leads to its displacement from plasma membrane & to subsequent cytoskeleton cleavage
- substrate for botulinum ADP-ribosyltransferase
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/P61586.html
- ↑ Atlas of Genetics & Cytogenetics in Oncology & Haematology http://atlasgeneticsoncology.org/genes/RHOAID42107ch3p21.html
- ↑ OMIM https://mirror.omim.org/entry/165370
- ↑ Kahn RA, Der CJ, Bokoch GM. The ras superfamily of GTP-binding proteins: guidelines on nomenclature. FASEB J. 1992 May;6(8):2512-3. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1592203
- ↑ Manser E, Leung T, Salihuddin H, Zhao ZS, Lim L. A brain serine/threonine protein kinase activated by Cdc42 and Rac1. Nature. 1994 Jan 6;367(6458):40-6. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8107774
- ↑ Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=387