Rho-guanine nucleotide exchange factor p190; p190RhoGEF (RGNEF, ARHGEF28, KIAA1998)
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Function
- RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of integrins & growth factor receptors
- functions in axonal branching, synapse formation & dendritic morphogenesis
- functions also in focal adhesion formation, cell motility & B-lymphocytes activation
- may regulate NEFL expression & aggregation & play a role in apoptosis (putative)
- phosphorylated on Tyr upon stimulation of cells by laminin (putative)
- forms a complex with MAPK8 & MAPK8IP1
- interacts with RHOA
- interacts with microtubules
- interacts with YWHAE & YWHAH
- interacts with PTK2
- interacts with NEFL (putative)
- interacts with CTNND2
- prevents interaction with RHOA
Structure
- homooligomer, forms cytoplasmic aggregates
- contains 1 DH (DBL-homology) domain
- contains 1 PH domain
- contains 1 phorbol-ester/DAG-type Zn+2 finger
Compartment
- cytoplasm (putative), cell membrane
- colocalizes with the microtubule radial & cortical systems (putative)
Alternative splicing
named isoforms=4