neurofilament light polypeptide; NF-L; neurofilament triplet L protein; 68 kD neurofilament protein (NEFL, NF68, NFL)

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Function

Structure

Pathology

Laboratory

Notes

More general terms

References

  1. Alperts et al Molecular Biology of the Cell, Garland Publishing, New York, NY 1989 pg 662
  2. Wang KK et al Calmodulin-binding proteins as calpain substrates. Biochem J 262:693 1989 PMID: https://www.ncbi.nlm.nih.gov/pubmed/2556106
  3. 3.0 3.1 Cairns NJ, Lee VM, Trojanowski JQ. The cytoskeleton in neurodegenerative diseases. J Pathol. 2004 Nov;204(4):438-49. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15495240
  4. UniProt http://www.uniprot.org/uniprot/P07196.html
  5. Inherited peripheral neuropathies mutation db http://www.molgen.ua.ac.be/CMTmutations/
  6. Human intermediate Filament mutation Database http://www.interfil.org
  7. GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=NEFL
  8. 8.0 8.1 Jenkins K Serum Biomarker May Predict Relapse in MS High NF-L levels could identify subclinical disease activity. MedPage Today. Nov 30, 2017
    Varhaug KN, Barro C, Bjornevik K et al Neurofilament light chain predicts disease activity in relapsing-remitting MS Neurol. Published Online Nov 29, 2017 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/29209636 <Internet> http://nn.neurology.org/content/5/1/e422
  9. 9.0 9.1 Olsson B, Portelius E, Cullen NC et al Association of Cerebrospinal Fluid Neurofilament Light Protein Levels With Cognition in Patients With Dementia, Motor Neuron Disease, and Movement Disorders. JAMA Neurol. 2018 Dec 3. PMID: https://www.ncbi.nlm.nih.gov/pubmed/30508027 https://jamanetwork.com/journals/jamaneurology/fullarticle/2716834

Database