neurodegenerative disease
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Etiology
- psychosocial stress may be associated with increased risk[6]
Pathology
- breakdown of the blood brain barrier occurs in many neurodegenerative disorders[4]
- neurodegenerative diseases appear to progress by spreading via brain connections[5]
Genetics
- defect or alteration in the expression of enzymes catalyzing the removal of ubiquitin from ubiquitin-proteins conjugates may be a characteristic of neurodegenerative diseases[3]
Laboratory
- CSF markers
More general terms
More specific terms
- AIDS dementia complex; AIDS encephalopathy; HIV-associated dementia (HAD)
- alcohol-associated dementia
- Alper's disease; progressive sclerosing poliodystrophy
- Alzheimer's disease (AD)
- amyotrophic lateral sclerosis (ALS); Lou Gerig's disease
- amyotrophic lateral sclerosis-parkinsonism-dementia complex of Guam
- argyrophilic grain disease (AgD)
- cerebellar degeneration
- Fahr's disease; striopallidodentate calcinosis; idiopathic basal ganglia calcification
- familial amyotrophy-dementia-parkinsonism
- familial British dementia (cerebral amyloid angiopathy ITM2B-related type 1, CAA-ITM2B1)
- familial Danish dementia (cerebral amyloid angiopathy ITM2B-related type 2, CAA-ITM2B2, heredopathia ophthalmo-oto-encephalica)
- familial progressive subcortical gliosis; familial dementia, Neumann type
- frontotemporal dementia; frontotemporal lobar degeneration; frontotemporal neurocognitive disorder (FTD, FTLD)
- hepatolenticular degeneration; Wilson's disease
- leukoencephalopathy, diffuse hereditary, with spheroids
- Levine-Critchley syndrome; neuroacanthocytosis; choreoacanthyocytosis
- limbic-predominant age-related TDP-43 encephalopathy (LATE); limbic-predominant amnestic neurodegenerative syndrome (LANS)
- McLeod syndrome; McLeod neuroacanthocytosis syndrome
- mesial temporal sclerosis; hippocampal sclerosis
- motor neuron disease
- multiple sclerosis (MS); includes clinically isolated syndrome
- neurodegeneration with brain iron accumulation
- neuronal intranuclear inclusion disease (NIID)
- normal pressure hydrocephalus (NPH)
- pallidopontonigral degeneration
- polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), presenile dementia with bone cysts; Nasu-Hakola disease
- polyglutamine expansion disorder
- progressive supranuclear palsy; Steele-Richardson-Olszewski syndrome (PSP)
- subacute combined degeneration of spinal cord; Lichtheim's disease; Putnam-Dana Syndrome
- synucleinopathy (includes alpha-synucleinopathy)
- tauopathy
- transmissible spongiform encephalopathy (prion disease)
References
- ↑ Cairns NJ, Lee VM, Trojanowski JQ. The cytoskeleton in neurodegenerative diseases. J Pathol. 2004 Nov;204(4):438-49. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15495240
- ↑ Arendt T. Neurodegeneration and plasticity. Int J Dev Neurosci. 2004 Nov;22(7):507-14. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15465280
- ↑ 3.0 3.1 UniProt http://www.uniprot.org/uniprot/P15374.html
- ↑ 4.0 4.1 Sweeney MD, Sagare AP, Zlokovic BV Blood-brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders. Nature Reviews Neurology. Jan 29, 2018 PMID: https://www.ncbi.nlm.nih.gov/pubmed/29377008 https://www.nature.com/articles/nrneurol.2017.188
- ↑ 5.0 5.1 Brown JA, Deng J, Neuhaus J et al Patient-Tailored, Connectivity-Based Forecasts of Spreading Brain Atrophy. Neuron. Oct 14, 2019 PMID: https://www.ncbi.nlm.nih.gov/pubmed/31623919 https://www.cell.com/neuron/fulltext/S0896-6273(19)30743-3
- ↑ 6.0 6.1 Song H, Sieurin J, Wirdefeldt K et al Association of Stress-Related Disorders With Subsequent Neurodegenerative Diseases. JAMA Neurol. Published online March 9, 2020. PMID: https://www.ncbi.nlm.nih.gov/pubmed/32150226 https://jamanetwork.com/journals/jamaneurology/fullarticle/2762514
- ↑ Sadlon A, Takousis P, Ankli B et al. Association of chronic pain with biomarkers of neurodegeneration, microglial activation, and inflammation in cerebrospinal fluid and impaired cognitive function. Ann Neurol 2023 Oct 3 PMID: https://www.ncbi.nlm.nih.gov/pubmed/37787094 Free article. https://onlinelibrary.wiley.com/doi/10.1002/ana.26804